Why insulin is not given orally?

Whenever you think about insulin many question come to mind including that why insulin is not given orally?. Also there are many such question for same are listed below.

  1. why insulin is not taken orally?
  2. are insulin injections painful?
  3. are insulin pumps safe?
  4. are insulin pumps good?
  5. can insulin be taken orally?
  6. how insulin pump works?
  7. how insulin injection works?
  8. where insulin is injected?
  9. where insulin can be injected?
  10. why insulin is not given intramuscularly?
  11. insulin without injection?
  12. insulin versus oral medication?

On analyzing above questions, you will find that most of them depict general understanding that insulin is administered using injection.

It is also known that even after all advances in world till now human kind is not able to decipher oral delivery mechanism for insulin.

Now what you think why is this of so much concern, Well lets look into following case.

Austin is 14 Yrs. teenager detected with Type-1 diabetes which requires constant administration of insulin. His parents have to constantly monitor his glucose levels.

Austin cannot play with children of his age group in his society. There is always a fear of hypoglycaemia (below normal drop in glucose level in blood) due to excess physical activity and he is in constant fear of this.

On top of this Austin is continuously suggested to maintain some kind of behavior by parents out of fear of hypoglycemia.

Austin is also afraid and has developed fear due to constant and daily administration of insulin injections on stomach, upper arm, upper leg and buttocks which not only causes pain but has led to localized injuries on these parts.

This fear leads to crying and opposition from Austin which leads to his parents delaying or withholding of insulin doses which sometime complicates the situation.

Also since the injections are to be taken before meals Austin sometimes tries to avoid meals altogether to avoid insulin injections.

In all insulin dependent type-1 diabetic cases patients fear or anxiety interferes in maintaining glycemic index.

Severe hypoglycemic episodes also make them reluctant to maintain insulin regime resulting in hyperglycemic episodes.

This hyperglycemic episode’s in turn leads to increase in doses of insulin leasing to vicious cycle in patients’ life.

Based on above case development of oral insulin tablets by University of British Colombia team is game changer. This discovery will save millions of diabetic individuals from above pain by replacing daily dreadful insulin injections before each meal.

This is also significant discovery as it is reported by University of British Colombia team that 100 % insulin from oral tablets is entering liver.

As reported no insulin was found in stomach even after 2 hours of oral insulin tablets administration in rats.

Earlier attempts to deliver insulin through oral solutions (drinkable insulin) led to accumulation of insulin in stomach.

By making the tablets non swallowing they have overcome biggest hurdle of absorption.

It is placed below tongue so that insulin is absorbed from thin lining membrane found in lining of inner cheek and below tongue.

Generally oral insulin tablets slowly release insulin over the period of two to four hours and same is case with this tablet but it starts to release insulin within half hour after taking it.

Though it cannot be denied that injection therapy is must in case of emergency as it acts instantly and fast due to direct delivery using injection.

It will save millions of diabetic individuals from multiple injection in a day. Further it will prevent environmental pollution as lot of syringes and plastic goes in landfill after disposal compared to tablets.

Further once mass produced tablets tend to be cheaper as compared to injections. Finally answer is found that why insulin is not given orally?

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